ESRD Patients

COPE: COVID-19 Antibody Testing of Patients with ESRD

What is the purpose of this study?

The purpose of this study is to examine levels of COVID-19 antibodies in ESRD patients undergoing hemodialysis who have gotten the COVID-19 vaccine. This knowledge will
lead to a better understanding how effectively the vaccine can help ESRD patients undergoing hemodialysis get immunity

The study does not provide the vaccine, and study team members will not be offering guidance as to whether or not one should receive a SARS-CoV-2 vaccine. If you will be receiving a vaccine and are interested in the study, we will collect a blood sample before vaccination, and collect samples at sequential time points after vaccination.

What is known about immunity to COVID-19?

The immune response, including duration of immunity to SARS-CoV-2 (the virus that causes COVID-19 infection) is not yet understood.

Where can I go for more information about the COVID-19 vaccine?

We have linked several resources for more information about COVID-19 and the vaccine in the tab “Vaccine Information” at the top of our website.

What does the study involve?

This study will involve the completion of a short survey focusing on COVID-19 and at-home, do-it-yourself blood collection which is designed to be simple and painless.

Please watch our Blood Collection Instructional Video for more information:

What are the eligibility criteria?

To be eligible for this study, you must be:
1. At least 18 years old
2. English-speaking
3. An ESRD patient receiving maintenance hemodialysis *
4. Planning to receive a COVID-19 vaccine when it becomes available

* We are unable to enroll patients that are receiving hemodialysis at home, or receiving peritoneal dialysis.

Can I participate if I already had COVID-19?

Yes

Can I participate if I have already received the COVID-19 vaccine?

Yes

How do I participate?

Fill out a short online form (below), which will determine your eligibility. If you are eligible to participate, then you will be contacted by our study team with further instructions on how to complete the survey and the blood collection once you get your vaccine. No in-person study visits will be required.

Will I receive my test results?

Yes, we will share your results with you as soon as your sample is tested.

What are antibodies?

Antibodies are proteins that are part of our immune system whose job it is to eliminate invaders, such as the virus that causes COVID-19.

Who has COVID-19 antibodies?

We expect anyone who has either been infected by or vaccinated for, the virus that causes COVID-19 to have antibodies against the virus. However, what is unknown is the level of antibody that is necessary to confer immunity.
Antibody levels do not necessarily imply protection; it is important to continue safety measures (mask wearing, social distancing) even if you develop COVID-19 antibodies.

Could I have COVID-19 antibodies without being infected by the virus?

Yes. In theory, your body creates COVID-19 antibodies after receiving the SARS-CoV-2 Vaccine

I have received convalescent plasma, Regeneron, or some other “antibody-based” therapy for COVID-19. Can I still participate?

Yes

Why are you studying ESRD patients?

ESRD patients undergoing hemodialysis may be less likely to mount a durable immune response and are often prevented from participating in vaccine trials. We hope to bridge this knowledge gap and learn more about the COVID-19 vaccine in ESRD patients undergoing hemodialysis.

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